Duo offers a variety of methods for adding two-factor authentication and flexible security policies to Microsoft Office 365 SSO logins, complete with inline self-service enrollment and Duo Prompt.
This video explains how to protect Microsoft Office 365 SSO logins using Duo’s on-premises SSO product, Duo Access Gateway. It describes some of the necessary prerequisites for this configuration and then shows the setup process beginning with enabling Active Directory federation to Office 365 using Duo Access Gateway.
Learn more about this configuration at https://www.duo.com/docs/o365. Learn more about Duo Access Gateway at https://www.duo.com/docs/dag.